Dr. William Seddon - Biography

Research Interests

My primary area of research is in cellular and molecular mechanisms of temperature acclimation in fish. We hope to gain a better understanding of how temperate fish adjust their biochemistry and physiology to compensate for long term changes in environmental temperature in the laboratory and in nature. We have also been exploring the possibility of using a cell culture model to better understand acclimation. I am also interested in the interaction of diet and temperature as they affect growth rate and development in channel catfish. We are investigating the possibility of enhancing growth at less than optimal temperatures by supplementing commercial catfish diets with various lipids. I have recently ventured into aquatic toxicology. We are currently investigating the effects of sublethal levels of manganese on the physiology of brook trout.

Recent Publications and Abstracts
 

• Seddon, W. L., and C. L. Prosser. 1999. Non-enzymatic isolation and culture of channel catfish hepatocytes using a collagenase-free perfusion system. Comp. Biochem. Physiol. 123A:9-15.
• Seddon, W. L. 1997. Mechanisms of temperature acclimation in the channel catfish Ictalurus punctatus: isozymes and quantitative changes. Comp. Biochem. Physiol. 118A (3):813-820.
• Seddon, W. L., and C. L. Prosser. 1997. Seasonal variations in the temperature acclimation response of the channel catfish, Ictalurus punctatus. Physiol. Zool. 70(1):33-44.
• Flickinger, Shane T., and William L. Seddon. 1998. Long term maintenance of in vivo function in cultured channel catfish hepatocytes. ASB Bulletin. 45(2): 86.
• Stanton, Kathleen, and William L. Seddon. 1998. Combined effects of dietary lipids and temperature on growth, protein, and lipid composition of channel catfish (Ictalurus punctatus) fingerlings. ASB Bulletin. 45(2): 87.
• Seddon, W. L., and C. L. Prosser. 1994. An improved method for preparation of channel catfish hepatocyte cultures. Am. Zool. 34(5):29A.
• Seddon, W. L., and C. L. Prosser. 1994. Seasonal variation in the acclimation response of the channel catfish, Ictalurus punctatus. Physiologist.