The Department of Biology is partially located in the Compton Science Center (CH), and also partially housed in Gunter Hall. Departmental facilities include following teaching and research laboratories:

An additional significant feature is the local environment. Frostburg State University is located high within the Allegheny Mountains, surrounded by mountain slopes, meadows, swamps, bogs, shale barrens, lakes, and streams. This variety of habitat provides students with a fine opportunity for ecological and environmental study in both natural and altered environments.